Impaired Ig class switch recombination

An impairment of the class-switch recombination process that normally leads B lymphocytes to produce IgG, IgA, or IgE.

What is Impaired Ig class switch recombination?

Impaired Ig class switch recombination is a symptom that people may experience for many reasons. It can be related to infections, chronic conditions, injuries, medication effects, or other health changes. The presence of this symptom alone does not diagnose any condition.

If you have Impaired Ig class switch recombination that is severe, persistent, or accompanied by other warning signs, contact a qualified healthcare provider.

Possible conditions associated with Impaired Ig class switch recombination

The following conditions have been associated with Impaired Ig class switch recombination. Only a health professional can determine the underlying cause.

hyper-IgM syndrome type 1

The X-linked variant of the Hyper-IgM syndrome. The affected individuals are virtually always male, because males only h...

Related symptoms

DiarrheaFailure to thriveHoarse voiceMuscle weaknessMyalgiaPeriorbital fullness

When to seek medical care

Seek urgent care if Impaired Ig class switch recombination is severe, sudden, or occurs with chest pain, difficulty breathing, confusion, severe weakness, or other serious symptoms.