hyper-IgM syndrome type 1

The X-linked variant of the Hyper-IgM syndrome. The affected individuals are virtually always male, because males only have one X chromosome, received from their mothers. Their mothers are not symptomatic, even though they are carriers of the allele, because the trait is recessive. Male offspring of these women have a 50% chance of inheriting their mother's mutant allele.

What is hyper-IgM syndrome type 1?

hyper-IgM syndrome type 1 is a medical condition. A condition is a disease, disorder, or abnormal state that affects the body or mind. This page provides educational information only and is not a diagnosis.

If you think you may have hyper-IgM syndrome type 1, speak with a qualified healthcare provider for evaluation and guidance.

Symptoms that may be associated with hyper-IgM syndrome type 1

DiarrheaFailure to thriveHoarse voiceImpaired Ig class switch recombinationMuscle weaknessMyalgiaPeriorbital fullness

When to seek medical care

Seek medical advice if you have symptoms that are severe, persistent, or affecting your daily life. Emergency care is needed for symptoms like chest pain, difficulty breathing, confusion, or severe weakness.